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Some vaccines hurt more than others due to factors like the injection method, vaccine ingredients, and individual sensitivity relating to genetics and age. Shots administered deep into the muscle, for instance, tend to be more painful than those given just under the skin. Using the correct needle size and the proper injection site can greatly reduce discomfort. If you're nervous about needles, adopting effective coping strategies can make the experience less stressful, improving your overall comfort during vaccinations. But have you ever wondered why some vaccines hurt more than others? Or what factors contribute to this pain? Let’s explore the world of the most painful vaccinations, from their causes and comparisons to effective coping strategies.